Abstract
BackgroundThis study investigated a large number of patients to develop a predictive nomogram for survival and a web-based survival rate calculator that can dynamically predict the long-term survival of patients with primary gastric diffuse large B-cell lymphoma.MethodsA total of 2647 patients diagnosed with primary gastric diffuse large B-cell lymphoma from 1998 to 2014 were extracted from the SEER database. We used the Lasso Cox regression model to identify independent risk factors for long-term survival and to develop a predictive nomogram for survival and a web-based survival rate calculator.ResultsThe median (mean) follow-up time was 30 months (52.8 months). Cancer-specific survival rates decreased with time, while the 5-year conditional survival increased with time. Cancer-specific deaths were not constant. Cancer-specific deaths of patients within the first 2 years were high, while the risk remained relatively constant after 2 years. The independent risk factors included surgery, chemotherapy, tumor stage and age, according to the Lasso Cox regression analysis. We developed a predictive nomogram and a web-based survival rate calculator (https://linjuli1991.shinyapps.io/dynnomapp/). The calibration plot suggested that the actual value exhibited good agreement with the predicted value.ConclusionsWe found that patients with primary gastric diffuse large B-cell lymphoma had a high risk of death during the first 2 years. Additional active follow-up strategies should be provided during this period. This is the first study to develop a predictive nomogram and a web-based survival rate calculator that can provide evidence for individual treatment and follow-up.
Highlights
This study investigated a large number of patients to develop a predictive nomogram for survival and a web-based survival rate calculator that can dynamically predict the long-term survival of patients with primary gastric diffuse large B-cell lymphoma
A total of 646 (24.4%) patients had tumors located in the upper part of the stomach, 666 (25.2%) patients had tumors in the lower part of the stomach, 292 patients (11%) had tumors in the whole stomach, and for 1043 patients (39.4%) the location was unknown
A total of 502 (19%) patients were treated with radiotherapy, and 2145 (81%) patients did not receive radiotherapy
Summary
This study investigated a large number of patients to develop a predictive nomogram for survival and a web-based survival rate calculator that can dynamically predict the long-term survival of patients with primary gastric diffuse large B-cell lymphoma. The National Comprehensive Cancer Network (NCCN) Guidelines use Ann Arbor staging of primary diffuse large B-cell lymphoma to guide clinical treatment and follow-up [1]. As a general staging system for non-Hodgkin’s lymphoma (NHL), the Ann Arbor staging system. Lin et al BMC Cancer (2019) 19:873 the probability of survival increasing over time based on survival times previously accumulated to guide treatment and follow-up strategies
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