Abstract
Successful neurotransmitter release depends on the tight association of a release competent transmitter vesicle and the calcium channel. Within small central synapses in the rodent brain the spatial organization of calcium channels has been proposed to be either, a stochastic distribution of single channels or clusters of 10-70 channels within the presynaptic membrane. Both scenarios result in a plausible description of the transmission properties of such synapses, characterized by measurements of the postsynaptic response and/or presynaptic calcium signals.
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