Dynamic Network Construction for Identifying Early Warning Signals Based On a Data-Driven Approach: Early Diagnosis Biomarker Discovery for Gastric Cancer.

Abstract

During the development of complex diseases, there is a critical transition from one status to another at a tipping point, which can be an early indicator of disease deterioration. To effectively enhance the performance of early risk identification, a novel dynamic network construction algorithm for identifying early warning signals based on a data-driven approach (EWS-DDA) was proposed. In EWS-DDA, the shrunken centroid was introduced to measure dynamic expression changes in assumed pathway reactions during the progression of complex disease for network construction and to define early warning signals by means of a data-driven approach. We applied EWS-DDA to perform a comprehensive analysis of gene expression profiles of gastric cancer (GC) from The Cancer Genome Atlas database and the Gene Expression Omnibus database. Six crucial genes were selected as potential biomarkers for the early diagnosis of GC. The experimental results of statistical analysis and biological analysis suggested that the six genes play important roles in GC occurrence and development. Then, EWS-DDA was compared with other state-of-the-art network methods to validate its performance. The theoretical analysis and comparison results suggested that EWS-DDA has great potential for a more complete presentation of disease deterioration and effective extraction of early warning information.