Abstract
A new method for modifying and fine-tuning liquid chromatographic separations without manipulating the mobile phase composition is discussed. This method, termed electrochemically modulated liquid chromatography (EMLC), is based on the electrochemical manipulation of the capacity factors (k' values) of analytes both prior to and during their elution from a column packed with nonporous glassy carbon (GC) spheres. The GC spheres are connected as the working electrode in the three-electrode electrochemical cell. Improvements in the separation of a mixture of aromatic sulfonates (ASFs) obtained at open circuit are demonstrated by the application of several fixed voltages (E[sub app]) as well as voltage and charge ramps to the column. A comparison of these separations to those obtained at various mobile phase combinations suggests that EMLC offers some potentially useful differences in retention that are not easily gained through compositional alterations of the mobile phase. 53 refs., 6 figs., 3 tabs.
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