Abstract
AbstractErythropoiesis was studied in the living fetal and neonatal rabbit liver in situ by in vivo microscopic and routine histologic methods. The results demonstrated in life: (1) that fetal hepatic erythropoiesis occurs extravascularly; (2) that individual erythroid cells late in their development pass by diapedesis from the extravascular compartment into the sinusoids; (3) that diapedesis occurs through the sinusoid wall in all parts of the hepatic lobule and possibly may be through the cytoplasm of the endothelial cells; and (4) that the sinusoid sphincters, the flow of blood through the sinusoids, and the intravascular adhesion of maturing erythroid cells to the endothelium affect the length of time that the erythroid cells remain in the sinusoids prior to their release into the peripheral circulating blood.
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