Abstract
Six chiral stationary phases based on N-substituted ( S-phenylglycinol were synthesised and dynamically loaded onto octadecyl-silica gel column. The effect of the alkyl (C 7, C 9, C 12) and aryl (methoxybenzyl, naphtylmethyl, anthrylmethyl) anchor moieties and influence of various chromatographic conditions (concentration of copper(II) ions, pH of the mobile phase, column temperature and organic modifier addition) on retention and enantioselectivity of the chiral columns toward selected α-amino acids were studied. The surface concentrations of chiral selectors, determined using the breakthrough method, were found to be in the range of 0.66–0.88 μmol/m 2. The order of elution of α-amino acid enantiomers was found to be R< S on the N-C 12-( S)-phenylglycinol and all N-aryl-( S)-phenylglycinol phases but a reversed elution order ( S< R) was observed on the N-C 7- and N-C 9-( S)-phenylglycinol phases.
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