Abstract

2-Benzenesulfonylcyclopentanone 1 and cyclohexanone 2 undergo efficient dynamic kinetic resolution on treatment with baker's yeast, under a range of conditions including in organic solvents, to form the corresponding cis-2-benzenesulfonylcycloalkanols 5 and 6 in excellent enantiopurity. Reduction of larger ring derivatives is much less efficient.

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