Dynamic Glycoprotein Hyposialylation Promotes Chemotherapy Evasion and Metastatic Seeding of Quiescent Circulating Tumor Cell Clusters in Breast Cancer.

Nurmaa K Dashzeveg ,Tsogbadrakh Dandar,Brian A Cobb ,Erika K Ramos ,Michael T Sokolowski ,Leonidas C Platanias ,Karen J Colley ,Priyam Patel,Lorenzo Gerratana,Valery Adorno-Cruz,Ami N Shah ,Hannah F Almubarak ,Rokana Taftaf,William A Müller ,Maroua Manai,Asif Shajahan,Carolina Reduzzi,Yuzhi Jia,Parastoo Azadi,Qiang Zhang,Emma J Schuster ,Massimo Cristofanilli,Huiping Liu,Paolo D’amico ,William J Gradishar ,Andrew D Hoffmann ,David Scholten,Youbin Zhang,Lamiaa El-Shennawy

doi:10.1158/2159-8290.cd-22-0644

Dynamic Glycoprotein Hyposialylation Promotes Chemotherapy Evasion and Metastatic Seeding of Quiescent Circulating Tumor Cell Clusters in Breast Cancer.

Nurmaa K Dashzeveg , Tsogbadrakh Dandar + Show 27 more

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https://doi.org/10.1158/2159-8290.cd-22-0644

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Journal: Cancer Discovery	Publication Date: Jun 5, 2023
Citations: 8	License type: CC BY-NC-ND 4.0

Affiliation: Northwestern University, University of Illinois at Chicago, Centro di Riferimento Oncologico, Istituti di Ricovero e Cura a Carattere Scientifico, University School, Case Western Reserve University, University of Georgia, Cornell University

#Metastasis Of Tumor Cells #Clusters In Cancer + Show 8 more

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Abstract

This study discovers that dynamic loss of terminal sialylation in glycoproteins of CTC clusters contributes to the fate of cellular dormancy, advantageous evasion to chemotherapy, and enhanced metastatic seeding. It identifies PODXL as a glycoprotein substrate of ST6GAL1 and a candidate target to counter chemoevasion-associated metastasis of quiescent tumor cells. This article is featured in Selected Articles from This Issue, p. 1949.

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