Dynamic evaluation of the correlativity between CD4 cell percentage and FEV1 can predict the balance of the state of the immune system in pulmonary graft versus host disease patients.

Abstract

Pulmonary graft versus host disease (GVHD) features irreversible airflow obstruction, which treatment typically involves immunosuppressive regimens. Regardless of whether GVHD is caused by immune overreaction or infection caused by immunologic suppression, the end result is death. Therefore, it is crucial to maintain a balance. We assessed 15 patients after hematopoietic stem cell transplantation (HSCT) in our hospital and collected CD4 cell percentage, forced expiratory volume in 1 s (FEV1) and FEV1/forced vital capacity (FVC) data from the same period. Here, we present a dynamic evaluation of the correlativity between the CD4 cell percentage and FEV1 that can predict state balance in pulmonary GVHD patients.