Abstract
Dynamic tissue perfusion measurement (DTPM) and single vessel flow measurement (SVFM) were assessed in differentiating inflammatory and malignant lesions of the pancreas. Sixty-nine patients (age 62.0 ± 14.7; 33 Female and 36 Men; 40 with malignant and 29 with inflammatory lesions) in whom during the endoscopic ultrasound (EUS) of focal pancreatic lesions it was possible to adequately evaluate the flow in the color Doppler, and then perform a biopsy, were qualified for the study. The assessed DTPM parameters flow velocity (TFV), perfusion intensity (TPI), and resistive index (TRI) as well as the following SVFM parameters: flow velocity (FV), volume flow (VolF), and resistive index (RI) differed significantly between the malignant and inflammatory lesions (p < 0.005). TFV and TPI have slightly better discriminatory properties than the corresponding FV and VolF parameters (p < 0.10). Considering the Doppler parameters usually evaluated in a given method, the TPI = 0.009 cm/s (sensitivity 79%, specificity 92%, AUC 0.899, p < 0.001) was significantly better (p = 0.014) in differentiating between inflammatory and malignant pancreatic lesions in comparison to FV = 2.526 cm/s (sensitivity 79%, specificity 70%, AUC 0.731, p < 0.001). Tissue perfusion has better discriminatory properties in the differentiation of solid pancreatic lesions than the Doppler blood flow examination in the single vessel within the tumor.
Highlights
Pancreatic cancer (PC) is one of the most malignant tumors [1,2]
With the use of external software, we showed the possibility of differentiating inflammatory pancreatic lesions from PC using organ perfusion parameters evaluated on the basis of the color Doppler [6,7]
All pancreatic tumor blood flow parameters evaluated by both methods differed significantly between the groups (Table 1)
Summary
Pancreatic cancer (PC) is one of the most malignant tumors [1,2]. Most of the patients at the time of diagnosis have advanced PC, which is unresectable. The 5-year mortality in patients with PC is still high, and the survival is poor [3]. The risk factors for pancreatic cancer include a history of the disease in the family, cigarette smoking, chronic pancreatitis, obesity, and diabetes mellitus. PC occurs most frequently in the 60 to 80 year age group, and its incidence is 50% higher in men than in women and individuals with genetic mutations [4]. It is a disease with an overall 5-year survival rate of less than 8%, as presently early detection methods or effective treatments are unavailable [5]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
