Abstract
Gene regulatory networks control metazoan development and determine which transcription factors will regulate which regulatory genes. However, development is a dynamic process that is driven by continuous change in time and space. Smith et al . now show how a network subcircuit controls a circular pattern of regulatory gene expression that sweeps outward from the vegetal pole of the sea urchin embryo and extinguishes its own activity in the more central regions to establish a dynamic regulatory pattern of gene expression. J. Smith, C. Theodoris, E. H. Davidson, A gene regulatory network subcircuit drives a dynamic pattern of gene expression. Science 318 , 794-797 (2007). [Abstract] [Full Text]
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