Abstract
Purpose: Physical activity is recommended for the general management of symptoms in OA patients. Despite this fact, mechanical loading is rarely a feature implemented in early drug screening tools. Pre-clinical and clinical studies have shown beneficial effects of loading on cartilage extracellular matrix (ECM) turnover and moderate exercise in joint mobility, respectively. Applying mechanical load to cartilage in ex vivo models may improve in vivo “likeness” and aid translation by promoting increased understanding of how the therapeutic potential of mechanical loading may interact with disease-modifying osteoarthritis drugs (DMOADs) in development.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
