Abstract
The relationship between brain and cognition is dynamic and may change across the lifespan. Age-related changes in brain structure/function are tied to changes in cognitive efficiency in normal aging, although the factors contributing to inter-subject differences have been scarcely investigated. One of the heuristics explaining such variance in cognitive aging is reserve (Stern et al., 2020), a construct suggesting that dynamic cognitive and underlying structural/functional brain processes cope with age-related brain changes in determining cognitive functioning. Here we investigated, in a large (N = 197) cross-sectional sample of healthy adults across the lifespan (18–77 years), the impact of age on dynamic cognitive reserve (dCR), i.e. measured cognitive abilities after confounding factors (gender, socio-economic status, brain volume and vascular lesion burden) have been removed.
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