Dynamic Changes of QRS Duration in Patients With Heart Failure

Abstract

Heart failure (HF) is a progressive disease in spite of optimal medical management. Cardiac resynchronization therapy is an effective therapy to reduce mortality, morbidity, and HF hospitalization in HF patients with systolic dysfunction and wide QRS duration. Clinical practice guidelines suggested that a defined QRS duration is used to determine if CRT should be used. This has an implicit assumption that a specific QRS duration defines whether the patient benefits from CRT and that QRS duration is static with minimal changes over time.