Dynamic changes of markers of endothelial function, hemostasis, fibrinolysis and inflammation in hospitalized patients with community-acquired pneumonia

Abstract

The aim was to estimate the role of parameters of systemic inflammation (C-reactive protein(CRP), fibrinogen), endothelial dysfunction (endothelin 1(ET-1)), hemostasis (protein C(PC)), fibrinolysis (D-dimer(DD) on different phases of treatment in patients with CAP. Material and Methods: The main group was 75 patients(pts) with moderate to severe CAP. The main group were divided into: subgroup 1–41 pts(moderate CAP), subgroup 2–34 pts(severe CAP). Blood coagulation test, biomarkers was performed at admission before antibacterial treatment (visit 1) and after clinical stability on 7–10 day(visit 2). Results: Levels of systemic inflammation and coagulation parameters in patients with moderate to severe CAP, Me [25-75%] Conclusions: In-patient cases of CAP are characterized by systemic inflammation and hypercoagulation. Normalization of PC is coming after 7–10 days of antibacterial treatment of CAP, vice versa ET-1, which reflects prolong endothelial dysfunction in patients with severe CAP. ET-1 and PC can be useful for establishment of coagulation disorders in pts with CAP.