Dynamic changes of lipid profile in severe hypertriglyceridemia-induced acute pancreatitis patients under double filtration plasmapheresis: a retrospective observational study

Huijun Zheng,Donghai Wang,Xiaoling Wang,Na Yang,Yueliang Chen,Yongjun Lin,Guo Feng,Zhihua Lu

doi:10.1186/s12944-020-01383-8

Huijun Zheng, Donghai Wang + Show 6 more

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https://doi.org/10.1186/s12944-020-01383-8

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Abstract

BackgroundTo investigate the dynamic change of lipid profile under double filtration plasmapheresis (DFPP) in severe hypertriglyceridemia-induced acute pancreatitis (sHTGP) patients and ascertain the association between these changes and the clinical prognosis.MethodssHTGP patients admitted within 72 h after disease onset were included, and all the patients received DFPP within 24 h after admission. Lipid profile were detected on admission, consecutive 4 days after DFPP and at discharge.ResultsThere were 47 sHTGP patients enrolled in this study. At admission, all the parameters of lipid profile changed significantly except for low density lipoprotein. In the first day after DFPP, the serum level of TG, cholesterol and very low density lipoprotein declined significantly, while the high-density lipoprotein (HDL) as well as apoprotein A1 elevated obviously (P < 0.05). TG maintained the downward trend in the following three days and the other parameters kept steady. Linear regression analysis showed that HDL was negatively correlated with the duration of hospitalization among three adjusted models (P = 0.043, P = 0.029, P = 0.025 respectively).ConclusionThere was distinct fluctuation of the lipid profile upon the burst of sHTGP and the parameters changed significantly in the first day after DFPP. Among these parameters, HDL may serve as a biomarker for disease prognosis in patients with sHTGP.

Highlights

To investigate the dynamic change of lipid profile under double filtration plasmapheresis (DFPP) in severe hypertriglyceridemia-induced acute pancreatitis patients and ascertain the association between these changes and the clinical prognosis
According to the 2012 Atlanta classification, 24% patients met the diagnostic criteria of severe acute pancreatitis (SAP). 48.9% patients had recurrent Acute pancreatitis (AP) and 36.1% patients were complicated with diabetes
According to whether they had AP recurrence, severe hypertriglyceridemia-induced acute pancreatitis (sHTGP) patients were divided into two groups: the non-recurrence and recurrence group

Summary

Introduction

To investigate the dynamic change of lipid profile under double filtration plasmapheresis (DFPP) in severe hypertriglyceridemia-induced acute pancreatitis (sHTGP) patients and ascertain the association between these changes and the clinical prognosis. Metabolic syndrome was proved to be closely related to the development and/or severity of AP [3, 4]. As one of the components of metabolic syndrome, severe hypertriglyceridemia (sHTG), defined as a serum triglyceride (TG) level > 11.3 mmol/L, is a common cause of AP [5, 6]. It has been found that the incidence of severe hypertriglyceridemia-induced acute pancreatitis (sHTGP) increased gradually and became the second common etiology of AP in China [7]. Lipoprotein metabolism disturbance has close association with the development and prognosis of sHTGP [8]. There was no systemic evaluation of lipid profile changes during sHTGP as so far

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