Dynamic changes in blood lipid levels and their associations with hypertensive disorders of pregnancy in twin pregnancy: A retrospective study

Abstract

Little knowledge onthe association of blood lipid levels with hypertensive disorders of pregnancy(HDP) in twin pregnancy. To investigate the associationof blood lipid levels with HDP in twin pregnancy. This is a retrospective study in the Beijing Birth Cohort on patients followed betweenJanuary 2014 andNovember 2021.A total of2628 women pregnant with twins were includedand dividedinto HDP (n=565) and normal blood pressure (NBP,n=2063) groups. HDP subtypes includedgestational hypertension (GH, n=190) and preeclampsia(PE,n=375). Dynamic changes in blood lipidprofiles and theirassociations with HDP were assessed. Compared to NBP group, higher triglyceride (TG) and low-density lipoprotein cholesterol (LDL-c) in the first (T1)and secondtrimesters (T2)existed in women with PE.In addition, TG increased significantly from T1 to T2,and HDL-c decreased significantly since T2 in women with PE, especially in women with early-onset PE and severe PE. Elevated TG and LDL-c were associated with HDP, mainlyPE.Ina subgroup analysis,higher TG or LDL-c increased the risk of HDP for underweight, overweight and primipara women. In twin pregnancy, women with PE had higher TG and LDL-c, and elevatedTG andLDL-cwere associated with PE. A significant increase inTG or decrease inHDL-cwere more prone to PE, especially early-onset PE and severe PE. It is helpful to monitorblood lipid levels in womenpregnant with twins, especially in underweight, overweight, and primipara women.