Abstract
The concept of the ‘presynaptic vesicular grid’ is briefly developed. It was postulated previously that this structure may have dynamic properties and that structural changes may be associated with changes in synaptic activity. Recent findings especially with the aid of the freeze etching method have demonstrated specific features of the presynaptic membrane that may be correlated with transmitter release. These features are far more pronounced in unanesthetized as compared with anesthetized preparations. Size and shape of the presynaptic vesicular grid may represent additional criteria of synaptic activity, although, direct evidence is still incomplete. The functional significance of the synaptic vesicular grid is mainly seen in the context of transient events. Nevertheless, longer lasting mechanisms, e.g., synaptic facilitation and potentiation may also be considered.
Published Version
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