Abstract
The photosensitive azobenzene-tethered DNA material provides an ideal force for DNA nanomachines. This work demonstrates the process of light-driven DNA strand displacement by physical and mathematical models. By data fitting, the strand displacement reaction rate constants under different sequence designs are discussed in detail. The results showed that the Gibbs free energy induced by azobenzene is around 2.52 kJ mol−1, which would hinder the light-driven strand displacement reaction. Increasing the length of the sticky ends can increase the displacement rate exponentially, but the displacement rate will not increase when it exceeds 12 bases.
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