Abstract
A significant role is played in inflammation by the liver, which, stimulated by inflammatory mediators, synthetizes plasma proteins with various dynamics. The purpose of these studies is to generate a detailed dynamic analysis of changes to concentrations of plasma and serum protein fractions and selected acute-phase proteins as well as nonspecific biochemical indices during the course of an induced pleurisy. The studies were conducted on female inbred Buffalo rats, which were divided into two groups: a control group (C) and an experimental group (IP) in which pleurisy was induced. In the IP group, significant changes in biochemical indices were observed between the 48th and 96th hours of pleurisy. A reduction of albumin, transferrin, urea, and creatinine concentrations was observed, while concentrations of the complement components C3 and C4, haptoglobin, and fibrinogen increased. An early increase of IL-1 was observed, while increases of IL-6 and TNF were noted in the later period. The maximum intensity of the processes described above occurred between the 72nd and 96th hours of pleurisy.
Highlights
IntroductionAfter a period of reduced blood supply, a local decrease in vascular resistance occurs as a result of histamine release, while, at a later stage, kinins appear, which cause changes in vascular permeability
630 Wroclaw, Poland 7 To whom correspondence should be addressed at Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, INTRODUCTION
At the 24th hour of inflammation, a significant reduction of albumin concentration is observed to be relative to the control value
Summary
After a period of reduced blood supply, a local decrease in vascular resistance occurs as a result of histamine release, while, at a later stage, kinins appear, which cause changes in vascular permeability. This leads to swelling as well as a local increase of temperature which can be observed thermovisually [1]. The first stage of the inflammatory reaction described above, related to the release of inflammatory mediators such as histamine, bradykinin, serotonin, and the occurrence of a pain reaction, is difficult to diagnose using laboratory tests At this stage, no shifts in the leukocyte image nor changes in the image of red blood cells and thrombocytes can be observed. In the first hours of inflammation, there are no significant changes in blood biochemical indices, such as the concentration of acute-phase proteins [7,8,9,10]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
