Abstract
Several types of microRNA (miRNA) overexpression in the brain are associated with stress. One of the targets of miR-34c is the stress-related corticotrophin releasing factor receptor 1 mRNA (CRFR1 mRNA). Here we will probe into the short-term effect and long-term effect of early adolescent traumatic stress on the expression of miR-34c and CRFR1 mRNA. Traumatic stress was established by electric foot shock for six consecutive days using 28-day rats. The anxiety-like behaviors, memory damage, CRFR1 protein, CRFR1 mRNA, and miR-34c expression were detected in our study. The results of our study proved that exposure to acute traumatic stress in early adolescent can cause permanent changes in neural network, resulting in dysregulation of CRFR1 expression and CRFR1 mRNA and miR-34c expression in hypothalamus, anxiety-like behavior, and memory impairment, suggesting that the miR-34c expression in hypothalamus may be an important factor involved in susceptibility to PTSD.
Highlights
Posttraumatic stress disorder (PTSD) is a prevalent anxiety disorder triggered by the traumatic experiences which produce strong negative feelings, such as horror, intense fear, and helplessness [1]
Previous studies have found that dicer1 and miR-17 expression were increased in reactive astrocyte, and it is reported that dicer1 plays an important role in astrocyte development [7]. miRNAs exert their function via base-pairing with complementary sequences within mRNA molecules
We focused on the short-term and long-term effects of adolescent foot shock on anxiety-like behavior, memory damage, protein CRFR1 expression, CRFR1 mRNA, and miR34c levels in the hypothalamus of male Wistar rats
Summary
Posttraumatic stress disorder (PTSD) is a prevalent anxiety disorder triggered by the traumatic experiences which produce strong negative feelings, such as horror, intense fear, and helplessness [1]. More studies pointed out that certain miRNAs may act as epigenetic modulators of gene expression in psychiatric disorders like autism, schizophrenia, major depression, and anxiety [10,11,12]; specific miRNAs were related to neuronal differentiation and synaptic plasticity and the treatment target of anxiety disorders [13]. Those studies indicated that the alterations of certain miRNAs expression had implication in pathogenesis of PTSD [10, 14]
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