Abstract
BackgroundWe investigated the correlation between texture features extracted from apparent diffusion coefficient (ADC) maps or diffusion-weighted images (DWIs), and grade group (GG) in the prostate peripheral zone (PZ) and transition zone (TZ), and assessed reliability in repeated examinations.MethodsPatients underwent 3-T pelvic magnetic resonance imaging (MRI) before radical prostatectomy with repeated DWI using b-values of 0, 100, 1,000, and 1,500 s/mm2. Region of interest (ROI) for cancer was assigned to the first and second DWI acquisition separately. Texture features of ROIs were extracted from comma-separated values (CSV) data of ADC maps generated from several sets of two b-value combinations and DWIs, and correlation with GG, discrimination ability between GG of 1–2 versus 3–5, and data repeatability were evaluated in PZ and TZ.ResultsForty-four patients with 49 prostate cancers met the eligibility criteria. In PZ, ADC 10% and 25% based on ADC map of two b-value combinations of 100 and 1,500 s/mm2 and 10% based on ADC map with b-value of 0 and 1,500 s/mm2 showed significant correlation with GG, acceptable discrimination ability, and good repeatability. In TZ, higher-order texture feature of busyness extracted from ADC map of 100 and 1,500 s/mm2, and high gray-level run emphasis, short-run high gray-level emphasis, and high gray-level zone emphasis from DWI with b-value of 100 s/mm2 demonstrated significant correlation, excellent discrimination ability, but moderate repeatability.ConclusionsSome DWI-related features showed significant correlation with GG, acceptable to excellent discrimination ability, and moderate to good data repeatability in prostate cancer, and differed between PZ and TZ.
Highlights
We investigated the correlation between texture features extracted from apparent diffusion coefficient (ADC) maps or diffusion-weighted images (DWIs), and grade group (GG) in the prostate peripheral zone (PZ) and transition zone (TZ), and assessed reliability in repeated examinations
Though the above studies dealt with cancers in the peripheral zone (PZ) and transition zone (TZ) together, Hambrock T et al [13] reported that ADC median showed a significant correlation with Gleason grade in PZ cancer
This study aimed to analyze the correlation between texture features extracted from ADC maps generated from several sets of two b-value combinations or DWIs with several b-values, and GG in the PZ and TZ, separately, and to evaluate the reliability of texture features in repeated examinations
Summary
We investigated the correlation between texture features extracted from apparent diffusion coefficient (ADC) maps or diffusion-weighted images (DWIs), and grade group (GG) in the prostate peripheral zone (PZ) and transition zone (TZ), and assessed reliability in repeated examinations. Though the above studies dealt with cancers in the peripheral zone (PZ) and transition zone (TZ) together, Hambrock T et al [13] reported that ADC median showed a significant correlation with Gleason grade in PZ cancer. Jyoti R et al [14] reported that ADC minimum was significantly correlated with GS in PZ cancer, but not in TZ cancer These results raise the possibility that DWIrelated features may demonstrate a different relationship with tumor aggressiveness between the PZ and TZ. In a recent systematic review, Surov A et al [15] reported that in PZ cancer, ADC moderately correlates with GS, but it weakly correlated with in TZ cancer
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