Duration of graft cold ischemia in long-term follow-up of orthotopic heart transplantation

Abstract

Aim. To evaluate the effect of the duration of graft cold ischemia on the long-term prognosis of orthotopic heart transplantation (OHT). Material and Methods . The study included 60 patients, who had receieved OHT in the Meshalkin National Medical Research Center since 2012. The influence of the duration of graft cold ischemia on the outcome of OHT in the long-term follow-up was evaluated. Survival, quality of life according to the SF-36 questionnaire, and parameters of cardiopulmonary exercise testing (CPET) were assessed. Results. The duration of graft cold ischemia in the study group was 210 (175 – 340) minutes. The minimum duration time was 158 minutes; the maximum duration time was 430 minutes. Graft ischemia for more than 240 minutes was registered in 42% of cases. The survival rate was 87% in the long-term follow-up. Exercise capacity of patients corresponded to the level above average or high: peak oxygen consumption was 17 (14.7 – 21.0) mL/min/kg with a threshold load power of 100 (90 – 120) W. The levels of quality of life based on the SF-36 questionnaire scoring were 53 (50 – 55) points for the physical component of health and 52 (50 – 56) points for the psycho-emotional component of health. No significant associations of graft cold ischemia duration were found with the survival rate, quality of life, and CPET parameters. Conclusion. The duration of graft cold ischemia did not show any negative effect on the results of OHT in the long-term followup. The study group of recipients was characterized by high survival rate and high exercise capacity in the long-term follow-up after OHT.