Abstract
SEVERAL authors1–4 have commented on the significant increase of the mitotic count (called ‘mitotic activity’ by many authors) shortly after application of methyl -cholanthrene and other carcinogens to the epidermis. The increased mitotic count has, as a rule, been interpreted as a sign of augmented growth, that is, an increased mitotic rate. The mitotic rate, defined as the number of cells that complete their mitoses per unit time, is related to the mitotic count and the mitotic duration as shown in the equation5 ; (mitotic rate) × (mitotic duration) = mitotic count.
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