Durability of angioplasty in treating severe leg ischaemia

Abstract

Abstract Background Percutaneous transluminal angioplasty (PTA) has recently been accepted as a valuable therapeutic option in patients with severe limb ischaemia. However, despite the increasing use of this technique, there have been concerns that the long-term efficacy of PTA is inferior to that of surgical revascularization. This prospective study reports the outcome of an unselected cohort of patients who underwent balloon angioplasty for severe lower limb ischaemia in a single centre. Methods During 1997, 108 patients with 133 severely ischaemic legs were treated by PTA. The median age of the patients (49 per cent men) was 76 years. Symptoms were rest pain in 31 per cent, ischaemic ulceration in 56 per cent and gangrene in 13 per cent. The distribution of risk factors was typical: diabetes 32 per cent, ischaemic heart disease 18 per cent and stroke 16 per cent. Median (interquartile range) follow-up was 16 (12–19) months. There was a mean of 1·7 angioplasty sites per patient, distributed in the iliofemoral (14 per cent), superficial femoral (42 per cent), popliteal (18 per cent) and crural (26 per cent) arteries. PTA was performed luminally in 20 per cent of cases and subintimally in the remainder. Overall, 67 per cent of the lesions were complete occlusions with a median length of 20 (10–40) cm. Results Technical success was achieved in 104 limbs, with 29 failures. The outcome of patients with a failed angioplasty (29) was poor, with 14 requiring bypass surgery, 11 undergoing a major amputation and 32 per cent dying after the procedure. In contrast, patients having a technically successful angioplasty had a good outcome after a median follow-up of 16 (12–19) months. In this group there was a 30 per cent overall mortality rate during follow-up. However, 85 per cent of the patients had no symptoms of critical ischaemia and the limb salvage rate was 92 per cent. Conclusion PTA is an effective and durable procedure in patients with critical leg ischaemia, with results comparable to those of historical surgical controls. Technical failure of PTA is, however, associated with a dire outcome.