Abstract
A jumping translocation (JT) involves a single donor chromosome and two or more recipient chromosomes in which a similar chromosomal region is translocated to various recipient chromosomes in different cell lines of a single individual. JTs are often associated with telomeric regions. Only 21 acquired JTs have previously been described in myeloid malignancies. Three of these cases involved the 3q13.31-qter region of which all were associated with a dismal outcome. In our recent publication, “Characterization of an acquired jumping translocation involving 3q13.31-qter in a patient with de novo acute monocytic leukemia” [1], we characterized the breakpoint region 3q13.31 by oligo-based array comparative genomic hybridization analysis. The present article provides data on copy number aberrations observed in the subtelomeric regions of this patient. Copy number alterations in the subtelomeric region have not been addressed previously in patients with JT.
Highlights
Duplication of subtelomeric regions in an adult with acute monocytic leukemia with an acquired jumping translocation involving 3q13.31-qter
A jumping translocation (JT) involves a single donor chromosome and two or more recipient chromosomes in which a similar chromosomal region is translocated to various recipient chromosomes in different cell lines of a single individual
Table and Figure Oligo-based array-comparative genomic hybridization was used to examine for copy number alterations Analyzed Purified DNA from bone marrow samples at the time of acute monocytic leukemia diagnosis and at the time of complete remission were compared Direct comparison by oaCGH analysis using purified DNA from time of complete remission as reference DNA allows to distinguishing whether observed copy number alterations are true copy number alterations or normal copy number variations Aarhus, Denmark
Summary
JTs are often associated with telomeric regions. 21 acquired JTs have previously been described in myeloid malignancies. Three of these cases involved the 3q13.31-qter region of which all were associated with a dismal outcome. “Characterization of an acquired jumping translocation involving 3q13.31-qter in a patient with de novo acute monocytic leukemia” [1], we characterized the breakpoint region 3q13.31 by oligo-based array comparative genomic hybridization analysis. The present article provides data on copy number aberrations observed in the subtelomeric regions of this patient. Copy number alterations in the subtelomeric region have not been addressed previously in patients with JT.
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