Duodenal perforations in the era of PPI; Is Lower Socioeconomic Status risk factor for peptic ulcer perforation? A Case Series.

Abstract

Peptic ulcer perforation is one of the most prevalent surgical emergencies worldwide, with mortality rates of up to 30%. The knowledge base for clinical decision making is limited due to a scarcity of high-quality studies on the disease, but there are a few published randomized trials. Despite the fact that Helicobacter pylori infection of the stomach and the use of nonsteroidal anti-inflammatory medicines are thought to be common causes, there are age, gender, perforation site, and underlying causes that differ by demographics. The mortality rates in different countries also differ. This case series includes five perforated peptic ulcers that were operated on and data collected during a four-month period between September and December 2021. There were no significant changes in other less frequent characteristics that could influence ulcer development in this cohort, including as dietary habits, alcohol usage, occupation, or any drugs they could be taking. However, among those with chronic H. pylori infection, the prevalence of low socioeconomic status, lack of vocational training or education, semiskilled and unskilled occupations, and high work-related energy expenditure may explain the previously reported link between low socioeconomic status, H. pylori infection, and perforated peptic ulcers.