Abstract
Penetration of the blood–brain barrier (BBB) and the blood–brain tumor barrier (BBTB) remains a significant challenge for the delivery of drugs in the treatment of glioma. Therefore, the development of targeted preparations with the ability to penetrate the BBB and BBTB, and target gliomas, is an important approach if we are to improve the efficacy of glioma treatment. In the current study, an active targeting preparation based on PLGA nanoparticles coated with erythrocyte membranes (RBCNPs) and dual-modified with DWSW and NGR peptide ligands (DWSW/NGR-RBCNPs). Euphorbia factor L1 (EFL1) extracted from euphorbiae semen was used as the model drug. The final nanoparticles were characterized by in vivo and in vitro tests. In vitro results showed that EFL1-loaded DWSW/NGR-RBCNPs were taken up by cells and had the ability to penetrate the BBB and BBTB and produce cytotoxic effects. Furthermore, in vivo studies in mice showed that when injected intravenously, these specialized NPs could enter the brain, target tumor tissue, and significantly extend life span. The results showed that dual-targeting EFL1-loaded DWSW/NGR-RBCNPs have significant potential as a nanotherapeutic tool for the treatment of brain glioma.
Highlights
Biomimetics has been recognized as an important mission in science and engineering for a long time
The DSPE-PEG2000-DWSW and DSPEPEG2000-NGR were used for the target modification of RBCNPs
These results suggest that the DWSW/NGR-RBCNPs could mitigate the toxicity of Euphorbia factor L1 (EFL1)
Summary
Biomimetics has been recognized as an important mission in science and engineering for a long time. The carrier materials or the carrier surface are modified according to the different purposes of use [1,2,3,4]. Such modification often fails to fully recognize complex endogenous substances in the body. Cell membrane biomimetic nanoparticles are realized by using natural cell membrane as the shell to encapsulate the synthesized nanoparticles. Through this strategy, the structure and function of the cell
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