Dual trigger with GnRH agonist (GnRHa) and varying doses of hCG increases the blastulation rate amongst high responders

Abstract

GnRHa trigger reduces ovarian hyperstimulation syndrome (OHSS) risk while maintaining acceptable clinical outcomes. The importance of sufficient LH stimulation is evidenced by improved oocyte yield and outcomes when adding hCG. However, there are little data addressing the issue as to whether the addition of an agonist induced FSH surge increases yield, or whether the presence of the endogenous surge allows a reduction in hCG without diminishing outcomes. This study evaluates the outcomes in GnRH-a trigger cycles with varying dose of hCG augmentation, comparing them to cycles triggered with hCG alone to determine if a dual trigger benefits high responders.