Dual‐Targeted Supramolecular Vesicles Based on the Complex of Galactose Capped Pillar[5]Arene and Triphenylphosphonium Derivative for Drug Delivery

Abstract

AbstractIn this study, a dual targeted supramolecular glycol‐vesicle based on the host‐guest complexation of galactose capped pillar[5]arene (GALWP5) and triphenylphosphonium derivative (D‐TPP) have been constructed (GALWP5⊃D‐TPP), which showed dual target potential (cell and mitochondria targeting) resulting from its galactose units and TPP units, respectively. The dual targeted glycol‐vesicle displays ignorable cytotoxicity and good mitochondria targeting. Our work presents a good example of rational design for an effective cell and subcellular organelles dual targeted delivery system.