Abstract
Type 2 diabetes is a multifactorial chronic disease triggered by genetic and/or environmental factors. Insulin resistance in peripheral organs is one of the major causes of type 2 diabetes. The brain organizes whole-body metabolism connecting tightly with the periphery. The hypothalamus is a key brain center which controls autonomic nerve balance and the hormonal system, including the hypothalamic-pituitary-adrenal (HPA) axis, by modulating hepatic glucose production, pancreatic insulin secretion and peripheral insulin sensitivity.
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