Abstract
A chronic metabolic disease that significantly affects people's health around the world is diabetes mellitus. High chronic fat intake is commonly associated with the development of insulin resistance, and hyperglycemia significantly alters the metabolism of lipids and carbohydrates. The objective of this review is to discuss the function of high-fat diet-induced diabetes mellitus, the mechanism at play, the various types of fats, and their impact on diabetes. DNA methylation, histone modifications, and an increase in the production of non-coding RNAs are some of the factors that might cause insulin resistance and lower the transcriptional activity of crucial genes for beta-cells. This meal pattern has been shown to improve insulin sensitivity and glycaemic control in persons with type 2 diabetes. High-fat diets have been related to better outcomes, but they can also increase insulin resistance and the beginning of type 2 diabetes.
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