Abstract
Glutathione (GSH) is one of the important substances to maintain the redox balance in vivo, accurate monitoring of its changes is conducive to the early diagnosis and treatment of related diseases. Herein, we reported a two-in-one nanoflower-structured sensing platform (ZCGO@MnO2) with luminescence resonance energy transfer (LRET) property and oxidase-like activity for dual-mode detection of GSH. The sensor consisted of persistent luminescence nanoparticles (PLNPs) with near-infrared emission and manganese dioxide (MnO2) with luminescence quenching ability and oxidase-like activity. The addition of GSH could reduce MnO2 to Mn2+, resulting in the recovery of persistent luminescence and inhibition of oxidase-like activity, then achieving persistent luminescence and colorimetric dual-mode signal outputs. The sensor utilized the persistent luminescence of PLNPs to eliminate the background interference of the complex biological matrix, improved the signal-to-noise ratio (S/N) of detection and took advantage of dual-mode sensing to improve the accuracy of detection, showing excellent analytical performance. Besides, the sensor was capable of monitoring changes in intracellular GSH levels through bioimaging. This work provides new ideas for the design of sensors in complex samples and broadens the application of PLNPs in the field of biosensing.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
