Abstract
We present novel pH and thermo-sensitive amphiphilic triblock copolymers with two hydrophilic poly(2-(di-methylamino)ethyl methacrylate) (DMAEMA) blocks flanking a central hydrophobic poly[(R)-3-hydroxybutyrate] block. The release of doxorubicin from the micelles can be controlled by pH and temperature triggers. Using this system, extremely long duration sustained drug release was achieved, better than most micelle systems currently described in the literature. Sustained release of the drug was achieved at pH 7 and 37 °C. Cytotoxicity tests of the copolymers showed that they have significantly lower toxicity towards fibroblast cells compared with the PDMAEMA homopolymer. The doxorubicin-loaded micelles were effective in controlling the growth of HeLa cells. The results demonstrated that the copolymers could be potentially used in chemotherapeutic applications.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
