Abstract
Dual-Resonance Long Period Grating in Fiber Loop Mirror Based Platform for Cheap Biomedical Sample Detection with High Resolution
Highlights
An optical fiber based sensor are very useful in many applications because of the compact size, electrical interference independence and suitability for remote sensing [1]
Due to filtering properties of the Fiber Loop Mirror (FLM), it provides possibilities of control of the wavelength spacing between interference dips, limitation of the temperature and strain cross- sensitivities and enhancement of the sensitivity of the specific sample detection [15].In this paper, for the first time of our knowledge, we present the combined structure of the Dual- Resonance Long Period Grating (DR-long period grating (LPG)) in the FLM for biotin-avidin reaction as a potential platform for medical application
All presented measurement data was performed in a fresh phosphate buffer saline (PBS) imitating human blood serum, and every step of functionalization process was followed by the DR-LPG excessive wash to remove weakly bonded biomolecules
Summary
An optical fiber based sensor are very useful in many applications because of the compact size, electrical interference independence and suitability for remote sensing [1]. The real-time detection, high sensitivity and accuracy are desire properties for the medical sensors in terms of the facilitate prompt disease diagnosis [3]. In spite of the high sensitivity of the LPG, the main asset is possibilities of modifying the optical structure with thin functional coatings in terms of facilitating highly selective and fast measurement in real time with the reported resolution of refractive index (RI) change up to 10−6 [4]. The LPG is an optical periodic structure, where transmission spectrum consists of the resonance dips at discrete wavelength [9]. When it comes to achieve very sensitive structure, the LPG should work close to the turning point, where the dual-resonance appears
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