Abstract
<p class="Abstract">The study was aimed to validate the traditional uses of <em>Polypodium vulgare</em> in disorders associated with smooth muscle contraction and to describe its possible underlying mechanism(s) by using <em>in vitro</em> and <em>in vivo</em> experimental techniques. Rhizome’s extract of <em>P. vulgare</em> reversed the high K<sup>+ </sup>(80 mM) and carbachol (1 µM) mediated contractions in isolated rabbit jejunum (5 and 10 mg/mL), trachea (5 and 10 mg/mL) and urinary bladder (3 and 10 mg/mL), with higher potency against carbachol than high K<sup>+</sup>, similar to dicyclomine. A rightward shift in carbachol cumulative response curves was observed in the presence of crude extract (1-3 mg/mL), similar to dicyclomine. Crude extract exhibited a dose-dependent (300-500 mg/kg) protective effect against castor oil-induced diarrhea in mice. Presence of dual blacked mechanism behind the smooth muscles relaxant effect of the crude extract, unveil medicinal significance of <em>P. vulgare</em> in GIT, respiratory and urinary bladder disorders.</p><p class="Abstract"><strong>Video clip</strong></p><p class="Abstract"><a href="https://youtube.com/v/Ya9Rhtlg3bE">Tissue preparation</a>: 3 min 5 sec</p><p> </p>
Highlights
Polypodium vulgare Linn. (Family: Polypodiaceae) is commonly known as Bisfaij, is indigenous to Europe, Africa and Eastern Asia (Ollgaard and Tind, 1993)
Qualitative analysis was performed for the presence of different chemical classes in the crude extract of P. vulgare (Evans and Trease, 1996; Akinyemi et al, 2005)
Qualitative analysis was performed for the presence of different chemical classes in the crude extract was found positive for the presence of alkaloids, carbohydrate, flavonoids, saponins, steroids, tannins and phenols
Summary
Polypodium vulgare Linn. (Family: Polypodiaceae) is commonly known as Bisfaij, is indigenous to Europe, Africa and Eastern Asia (Ollgaard and Tind, 1993). (Family: Polypodiaceae) is commonly known as Bisfaij, is indigenous to Europe, Africa and Eastern Asia (Ollgaard and Tind, 1993). Plant has been used medicinally as anti-epileptic (Khory and Katrak, 1981), cardiotonic, anti-spasmodic and digestive. It is effective in piles, leprosy, bronchospasm, melancholia and rheumatic disorders (Dar et al, 2012). Rhizomes of P. vulgare are used as remedy for cough and common cold (Ollgaard and Tind, 1993). Rhizomes of P. vulgare are used as sweetener (Dar et al, 2012)
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