Abstract
Tremendous breakthroughs in nanotechnology have fuelled an explosion of highly refined and tailored drug methods in recent years. Sensor-based nanocarriers are establishing themselves as an intriguing frontier, potentially reshaping the terrain of precision medicine. pH-based nanocarriers have received interest for their potential to improve cancer therapy by taking advantage of the acidic environment of tumor tissues, therefore tackling the centuries-old dilemma of selectively attacking malignant cells while sparing healthy ones. In synergy with the promising potential of pH-based nanocarriers to redefine cancer therapy, ultrasound emerges as a pivotal element in this transformative journey. As a non-invasive, non-ionizing, cost-effective, safe, and portable imaging modality, ultrasound seamlessly integrates with nanocarriers. They propel us closer to a fascinating future in which accurate tumor-specific medication administration and imaging become commonplace. While ultrasonic responsiveness improves the transport and distribution of therapeutic agents through enhanced permeability and mechanically triggered drug release, pH sensitivity assures regulated medication release at specific diseased locations. Intense research efforts over the past decade have brought pH-ultrasound-based nanocarriers to the forefront of cancer treatment, providing individuals confronting this deadly disease fresh hope. Recent developments in this field have opened novel opportunities for cancer therapies and tailored medication delivery. While ultrasonic responsiveness improves the transport and distribution of therapeutic agents through enhanced permeability and mechanically triggered drug release, pH sensitivity assures regulated medication release at specific diseased locations. The exceptional potential of pH and ultrasound based nanocarriers is explored in this comprehensive review, ushering in a hopeful age of precision medicine as well as cancer therapies.
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