Abstract
Introduction: Pterygium is a common ophthalmic problem in the Middle East where exposures to dust and sun rays are risk factors. The condition is more prevalent in middle-aged males and can be considered as an aging process. The aim of this study is to test both the degenerative and the proliferative components of Pterygium by both reduced glutathione and topoisomerase one activity. Methods: The study applied immunohistochemistry staining for both reduced glutathione and topoisomerase 1. Results: The samples expressed positive glutathione staining in most primary Pterygium conditions and all secondary Pterygium. On the other hand, the topoisomerase 1 immunohistochemistry expressed focal activity in secondary conditions suggesting a progenitor cell role in the pathogenesis of Pterygium in conjunction with oxidative stress. Conclusion: Pterygium represents dual pathology with a proliferative component and a degenerative one that needs further studies. It is possible to use combination immunohistochemistry markers to predict the prognosis of Pterygium behavior.
Highlights
Pterygium is a common ophthalmic problem in the Middle East where exposures to dust and sun rays are risk factors
Pterygium is a possible aging-related condition that is associated with collagen degeneration
This degeneration expressed fibro-vascular reaction creeping over the cornea
Summary
Pterygium is a common ophthalmic problem in the Middle East where exposures to dust and sun rays are risk factors. The condition is more prevalent in middle-aged males and can be considered as an aging process. The aim of this study is to test both the degenerative and the proliferative components of Pterygium by both reduced glutathione and topoisomerase one activity. Pterygium is a possible aging-related condition that is associated with collagen degeneration. This degeneration expressed fibro-vascular reaction creeping over the cornea. Sunrays and exposure to dust are risk factors for this condition. A widespread meta-analysis study on more than 400 000 candidates worldwide demonstrated increasing rates of Pterygium cases with age predominantly in males exposed to sun rays.
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