Abstract
High stability of selenium nanoparticles (SeNPs) is crucial for preserving their biochemical properties. Currently, surface modification is one of the most effective routes to improve the stability of nanoparticles. Herein, we synthesized SeNPs through a mild reduction reaction at room temperature. Subsequently, the SeNPs were simultaneously coated with polyvinylpyrrolidone (PVP) and glucose to improve stability, the obtained composite was abbreviated as PG-SeNPs. Results demonstrated that PG-SeNPs displayed excellent stability without any coagulation even when stored for as long as 2 months. The hydrodynamic particle size remained almost uniform. After that, doxorubicin (DOX) was loaded onto the surface of PG-SeNPs via electrostatic interaction, resulting in PG-SeNPs@DOX, with a loading efficiency of 4.53±0.3%. In addition, the biocompatibility of PG-SeNPs was conducted and proven to be excellent. Consequences obtained in both in the in vitro and in vivo studies revealed that the PG-SeNPs@DOX could effectively kill the tumor cells and remarkably inhibit the growth of the transplanted tumor. We proposed that the antitumor efficacy obtained above was primarily dominated by the synergistic effect of both the reactive oxygen species induced by SeNPs and the released DOX. In summary, this study presents a straightforward and plausible method for producing highly stable SeNPs, and further confirms the antitumor effectiveness of PG-SeNPs@DOX.
Published Version
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