Dual Key-Activated Nir-I/Ii Fluorescence Probe for Monitoring Photodynamic And Photothermal Synergistic Therapy Efficacy.

Abstract

As the cancer markers, H2 O2 and viscosity play an essential role in the development of tumors. Meanwhile, based on the performance of near-infrared (NIR) fluorescence imaging and the high efficiency of PDT and PTT synergistic therapy, it is urgent to develop a dual-key (H2 O2 and viscosity) activated fluorescence probe for cancer phototherapy. Herein, a NIR-I/II fluorescence probe named BX-B is reported. In the presence of both H2 O2 and viscosity, the fluorescence signal of NIR-I (810nm) and NIR-II (945nm) can be released. In the presence of H2 O2 , the PDT and PTT effects are shown. BX-B has been used to monitor its therapeutic effects in cancer cells and tumor-bearing mice due to the increased viscosity caused by PDT and PTT. In addition, the tumors of mice treated with BX-B are almost completely ablated after the laser irradiation based on its PDT and PTT synergistic therapy. This work provides a reliable platform for effective cancer treatment and immediate evaluation of therapeutic effects. This article is protected by copyright. All rights reserved.