Abstract

Mixed infections with two or three types of virus in cultured cells have been studied by several investigators. Experimental infection of single cells with two different animal viruses have been reported ( 1-4). Furthermore, replication of murine and feline C-type viruses in a human lymphoblastoid cell line carrying EB herpesvirus (5) and budding of vesicular stomatitis virus in a reptile cell line carrying C-type virus (6) have been noted. However, a naturally occurring dual infection with both C-type virus and herpesvirus in the same cultured cells has not been extensively explored. The present paper describes such a dual infection with guinea pig C-type virus (GPCV) and guinea pig herpes-like virus (GPHLV) in cell cultures derived from normal guinea pigs. The successful activation of the two endogenous viruses in guinea pigs was dependent upon the conditions under which the cultured cells were maintained. Materials and Methods. Source of guinea

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