Abstract
Tumor cell resistance is one of the big hurdles limiting the therapeutic efficacy of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-based cancer treatment. Therefore, the development of a safe and effective sensitizer agent is greatly desired for optimizing TRAIL therapy. Herein, we successfully developed a Se/Fe complex with low toxicity to highly effectively inhibit tumor cells proliferation and migration capabilities through down-regulating ER stress related selenoproteins. Furthermore, it could more efficiently damage tumor spheroids with good penetration capability. More importantly, it could synergize with TRAIL treatment to induce the robust generation of reactive oxygen species (ROS), down-regulating ER stress related selenoproteins for triggering tumor cells apoptosis in extrinsic and intrinsic signaling pathways. Taken together, this study provides a potential chemo-drug and sensitizer agent to improve the therapeutic efficacy of TRAIL-based cancer treatment
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