Dual-Functional Iron Oxide Nanoparticles Coated with Polyvinyl Alcohol/5-Fluorouracil/Zinc-Aluminium-Layered Double Hydroxide for a Simultaneous Drug and Target Delivery System.

Mona Ebadi,Saifullah Bullo,Giorgia Pastorin,Kalaivani Buskaran,Mohd Zobir Hussein,Sharida Fakurazi

doi:10.3390/polym13060855

Abstract

Iron oxide nanoparticles are suitable for biomedical applications owing to their ability to anchor to various active agents and drugs, unique magnetic properties, nontoxicity, and biocompatibility. In this work, the physico-chemical and magnetic properties, as well as the cytotoxicity, of Fe3O4 nanoparticles coated with a polymeric carrier and loaded with a 5-fluorouracil (5-FU) anti-cancer drug are discussed. The synthesized Fe3O4 nanoparticles were coated with polyvinyl alcohol and Zn/Al-layered double hydroxide as the drug host. The XRD, DTA/TG, and FTIR analyzes confirmed the presence of the coating layer on the surface of nanoparticles. The results showed a decrease in saturation magnetization of bare Fe3O4 nanoparticles after coating with the PVA/5FU/Zn/Al-LDH layer. In addition, the presence of the coating prevented the agglomeration of nanoparticles. Furthermore, the pseudo-second-order equation governed the kinetics of drug release. Finally, the coated nanoparticles showed stronger activity against liver cancer cells (HepG2) compared to that of the naked 5-FU drug, and displayed no cytotoxicity towards 3T3 fibroblast cell lines. The results of the present study demonstrate the potential of a nano delivery system for cancer treatment.

Highlights

In recent years, the application of new materials and the efficiency of the products have been considerably improved using nanomaterial technology [1]
The formation of the maghemite phase is unlikely, owing to the fact that the synthesis was conducted under non-oxidative conditions [23]
The IC50 of the FPVAFU-ZLDH nanoparticles was found to be 11.43 μg/mL. These findings propose a more efficient anticancer activity of FPVAFU-ZLDH nanoparticles than a pristine

Summary

Introduction

The application of new materials and the efficiency of the products have been considerably improved using nanomaterial technology [1] The reason for this is that the properties of nanomaterials dramatically change and become unique in a nano-sized regime. Cancer is one of the most lethal diseases [2,3,4] Treatment methods such as chemotherapy can be potentially useful for cancer treatment, but non-cancerous tissues and other parts of the body are usually affected [5]. For this reason, researchers have exploited nanotechnology for cancer treatment. The magnetic nanoparticles act as carriers to transport the drugs [10]

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