Dual functional factors induced antibacterial performance within metal-organic framework

Abstract

Baicalein (BA) is a natural compound with broad-spectrum antibacterial effects, achieved by disrupting bacterial cell membranes or inhibiting enzyme activity. However, the antibacterial efficacy of berberine is limited, and long-term use may lead to the development of resistance. Here, we have successfully developed a novel antibacterial nanoplatform, BA&ICG@ZIF-8, through in situ self-assembly. BA&ICG@ZIF-8 demonstrates excellent photothermal conversion capability, and the synergistic antibacterial effect between BA and ZIF-8 significantly enhances the antibacterial ability of BA. Under the condition of additional near-infrared laser, the combined action of BA, indocyanine green (ICG), and ZIF-8 further enhances the antibacterial performance of BA&ICG@ZIF-8. This study provides insights for the rational design of antibacterial nanoplatforms based on the in situ self-assembly strategy and the improvement of antibacterial properties of natural products.