Abstract
Metal complexes of the type [M(L)2] 1–3, (M = Co(II), Ni(II) and Cu(II)) of ligand (LH = 2-benzo[d]thiazol-6-ylimino)methyl)benzene-1,4-diol, have been synthesized and characterized by elemental analysis, NMR, Infrared, UV–Visible, ESI-Mass, magnetic moments and ESR spectroscopic methods. Based on spectral data a square planar geometry has been proposed for all the complexes. The interaction of metal complexes with CT-DNA was investigated using UV–Vis absorption and fluorescence spectroscopy. The absorption and fluorescence spectral studies indicate a non-covalent interaction between the metal complexes and DNA base pairs. The competitive studies revealed that the complexes could interact the DNA through an intercalative mode and induce oxidative and photolytic DNA cleavage mediated by reactive oxygen species (ROS), and it is found that the Cu(II) complex cleaved DNA more effectively compared to Co(II) and Ni(II) complexes. In addition, antimicrobial activity of all the complexes was also examined.
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