Dual effect of HGF on satellite/myogenic cell quiescence. Focus on “High concentrations of HGF inhibit skeletal muscle satellite cell proliferation in vitro by inducing expression of myostatin: a possible mechanism for reestablishing satellite cell quiescence in vivo”

Abstract

adult skeletal muscle shows a very high level of plasticity that is necessary for adaptation to various conditions. Moreover, it possesses the remarkable capacity to regenerate after injury, and such plasticity derives from the properties of satellite cells—a group of cells that restore muscle