Abstract
Background Delayed Enhanced MRI (DEMRI) with gadolinium (Gd) is used as gold standard for diagnosis of myocardial infarction. However, the non-specific property of Gd overestimates the infarct size. Conversely, manganese (Mn2+) enters only the live, active cardiomyocytes via L-type Ca2+ channels. From our earlier work in animal MI models, manganese-enhanced MRI (MEMRI) has demonstrated its utility in identifying the viable, nonviable, and injured myocardium. We performed the “first in human” dual-contrast MEMRI-DEMRI to assess the efficacy of MEMRI-DEMRI to identify the periinfarct region (PIR) in patients with severe ischemic cardiomyopathy (ICM).
Highlights
Delayed Enhanced MRI (DEMRI) with gadolinium (Gd) is used as gold standard for diagnosis of myocardial infarction
We performed the “first in human” dual-contrast manganese-enhanced MRI (MEMRI)-DEMRI to assess the efficacy of MEMRI-DEMRI to identify the periinfarct region (PIR) in patients with severe ischemic cardiomyopathy (ICM)
LV functional images and DEMRI were acquired on the first day of this study, and MEMRI was acquired on the following week
Summary
Dual contrast enhanced cardiac MRI using manganese and gadolinium in patients with severe ischemic cardiomyopathy detects the peri-infarct region (PIR). Yuka Matsuura1*, Rajesh Dash, Paul J Kim, Hadas Shiran, Aparna Bhagavat, Phillip Harnish, Michael V McConnell, Phillip Yang. From 17th Annual SCMR Scientific Sessions New Orleans, LA, USA. From 17th Annual SCMR Scientific Sessions New Orleans, LA, USA. 16-19 January 2014
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