Dual-carrier drug-loaded composite membrane dressings of mesoporous silica and layered double hydroxides

Abstract

Nowadays functional dressings are used as wound coverings, which can temporarily replace damaged skin and act as a temporary barrier, and can deliver drugs and reduce wound infections. In this study, amoxicillin sodium was loaded into synthetic layered double hydroxides (LDH) and dendritic mesoporous silica nanoparticles (DMSNs), combined with electrospinning technology to load on the polycaprolactone (PCL) fibrous membrane to obtain a composite fibrous membrane dressing. The synthesized LDH and DMSNs were characterized by XRD, FT-IR, TGA, SEM, TEM and N2 adsorption/desorption. In vitro cytotoxicity experiments confirmed that the synthesized LDH and DMSNs had no cytotoxicity. The hydrophilicity of the composite membrane was greatly improved after adding the two drug-loaded particles, and the water absorption rate could reach more than 300%. The water contact angle decreased from 128° to 115°. Antibacterial experiments confirmed that membrane A and membrane B can effectively inhibit Staphylococcus aureus and Escherichia coli. In the drug release experiment, the drug release time of the two composite membranes could be extended to 144 h due to the increase in the content of drug-loaded particles. The drug release rate of composite membrane A was 87.81%. The drug release rate of composite membrane B was 94.65%. Among them, because the membrane B wrapped the drug-loaded particles more completely, the drug can be released smoothly and slowly.