Abstract
The first chemoselective N-imination of indoles with isocyanides by using an N-heterocyclic carbene (NHC) as an organocatalyst was achieved. A concurrent activation of nucleophile (indole) and electrophile (isocyanide) took place facilitated by the novel NHC organocatalysis via initial activation of isocyanide. The in situ generated indole anion and imine-azolium species performed a coupling reaction, producing several new indole-based formamidines in high yields under mild conditions, which was not feasible via previously reported strategies.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
