Abstract
Aims: To describe the immune response of preterm infants to combined diphtheria/tetanus/5 component acellular pertussis-Haemophilus influenzae type b inactivated polio vaccine (DT5aP-Hib-IPV) and meningococcal serogroup C conjugate vaccine (MCC) under...
Highlights
We have investigated the response of preterm infants to a combined DT5aP-Hib-inactivated polio vaccine (IPV) containing aluminium phosphate adjuvant given at the same time as a meningococcal serogroup C vaccine under the United Kingdom’s accelerated schedule
The availability of a combined DT5aP-Hib-IPV vaccine that elicits protective responses to its various antigens presents an attractive choice for use in the preterm infant population
Acellular pertussis vaccines have a reduced side effect profile compared to whole cell pertussis vaccines and those containing five pertussis components have been shown to have an efficacy against pertussis infection equivalent to that seen with a UK whole cell pertussis vaccine.[16]
Summary
Aims: To describe the immune response of preterm infants to combined diphtheria/tetanus/5 component acellular pertussis-Haemophilus influenzae type b inactivated polio vaccine (DT5aP-Hib-IPV) and meningococcal serogroup C conjugate vaccine (MCC) under accelerated schedule. After three doses of vaccines Hib polysaccharide IgG geometric mean concentration (GMC) was 1.21 mg/ml with 80% >0.15 mg/ml; MCC serum bactericidal assay geometric mean titre (GMT) was 1245 with 100% >8.
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